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Catalog#: C-1146 Quantity: 5mg Targets: IAP Synonym: GDC0917; GDC-0917; GDC 0917; CUDC427; CUDC-427; CUDC 427 Chemical Name/IUPAC:(S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide
Product Name: GDC-0917 Chemical Formula: C29H36N6O4S Molecular Weight: 564.7 CAS#: 1446182-94-0 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GDC-0917 is an orally available, monovalent mimetic of Smac/DIABLO and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways.