GDC-0917

SKU: C-1146-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$189.99

Catalog#: C-1146

Targets: IAP

Synonym: GDC0917; GDC-0917; GDC 0917; CUDC427; CUDC-427; CUDC 427

Chemical Name/IUPAC:(S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide

Technical Data

Product Name: GDC-0917

Chemical Formula: C29H36N6O4S

Molecular Weight: 564.7

CAS#: 1446182-94-0

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
GDC-0917 is an orally available, monovalent mimetic of Smac/DIABLO and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways.

GDC-0917

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