SKU: C-1144
GDC-0623
$120.00
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  • Catalog#: C-1144
  • Quantity: 5mg
  • Targets: MEK
  • Synonym: GDC0623; GDC-0632; GDC 0632
  • Chemical Name/IUPAC:5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
    Technical Data
  • Product Name: GDC-0623
  • Chemical Formula: C16H14FIN4O3
  • Molecular Weight: 456.21
  • CAS#: 1168091-68-6
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.