GDC-0449 (Vismodegib)
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Technical Data
Description
GDC-0449 (Vismodegib) is a potent, orally bioavailable hedgehog antagonist with antineoplastic activity. GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.