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GDC-0449 (Vismodegib)

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SKU: C-1143-5mg
GDC-0449 (Vismodegib) Chemical Formula: C19H14Cl2N2O3S
$45.99
  • Catalog#: C-1143
  • Targets: Hedgehog
  • Synonym: GDC0449; GDC 0449; GDC-0449; RG3616; RG 3616; RG-3616. Vismodegib; Erivedge
  • Chemical Name/IUPAC:2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
    Technical Data
  • Product Name: GDC-0449 (Vismodegib)
  • Chemical Formula: C19H14Cl2N2O3S
  • Molecular Weight: 421.3
  • CAS#: 879085-55-9
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    GDC-0449 (Vismodegib) is a potent, orally bioavailable hedgehog antagonist with antineoplastic activity. GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.


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