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Catalog#: C-1141 Quantity: 5mg Targets: PI3K Synonym: RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084 Chemical Name/IUPAC:5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine
Product Name: GDC-0084 Chemical Formula: C18H22N8O2 Molecular Weight: 382.42 CAS#: 1382979-44-3 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GDC-0084 is a potent PI3K inhibitor with antineoplastic activity. GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis.