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Catalog#: C-1139 Quantity: 5mg Targets: PI3K Synonym: GDC0032; GDC0032; GDC 0032; RG7604; RG7604; RG 7604; Taselisib Chemical Name/IUPAC:2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide
Product Name: GDC-0032 (Taselisib) Chemical Formula: C24H28N8O2 Molecular Weight: 460.53 CAS#: 1282512-48-4 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
GDC-0032 (Taselisib) is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0.2nM, and with reduced inhibitory activity against PI3K?. GDC-0032 preferentially inhibited PIK3CA mutant cells relative to cells with wild-type PI3K. GDC-0032 potently inhibits signal transduction downstream of PI3K and induces apoptosis at low concentrations in breast cancer cell lines and xenograft models that harbor PIK3CA mutations.