SKU: C-1130-5mg
C32H37N5O3 Solid Powder
  • Catalog#: C-1130
  • Quantity: 5mg
  • Targets: EZH2
  • Synonym: EPZ005687; EPZ 005687; EPZ-005687; EPZ5687; EPZ-5687; EPZ 5687
  • Chemical Name/IUPAC:1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
    Technical Data
  • Product Name: EPZ-005687
  • Chemical Formula: C32H37N5O3
  • Molecular Weight: 539.66
  • CAS#: 139772--26-1
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    EPZ-005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ-005687 reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild-type cells.