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Catalog#: C-1130 Quantity: 5mg Targets: EZH2 Synonym: EPZ005687; EPZ 005687; EPZ-005687; EPZ5687; EPZ-5687; EPZ 5687 Chemical Name/IUPAC:1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Product Name: EPZ-005687 Chemical Formula: C32H37N5O3 Molecular Weight: 539.66 CAS#: 139772--26-1 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
EPZ-005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ-005687 reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild-type cells.