EPZ-005687
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Technical Data
Description
EPZ-005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ-005687 reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild-type cells.