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Catalog#: C-1118 Targets: FACT Synonym: CBL-0137; CBL0137; CBL 0137 Chemical Name/IUPAC:1,1'-(9- (2-(isopropylamino)ethyl)- 9H-carbazole- 3,6-diyl)bis(ethan-1-one)
Product Name: CBL-0137 Chemical Formula: C21H24N2O2 Molecular Weight: 336.43 CAS#: 1197996-80-7Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
Dacomitinib (PF-00299804) is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.