SKU: C-1117
Dacomitinib (PF-00299804)
$70.00
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  • Catalog#: C-1117
  • Targets: EGFR
  • Synonym: PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF299; PF 299; dacomitinib
  • Chemical Name/IUPAC:(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
    Technical Data
  • Product Name: Dacomitinib (PF-00299804)
  • Chemical Formula: C24H25ClFN5O2
  • Molecular Weight: 469.93
  • CAS#: 1110813-31-4
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    Dacomitinib (PF-00299804) is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.