CH-5132799
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Technical Data
Description
CH5132799 is a potent, orally available class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3K? (IC(50)=0.014 ?M). Tumors harboring PIK3CA mutations were significantly sensitive to CH-5132799 in vitro and were remarkably regressed by CH-5132799 in in vivo mouse xenograft models.