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Catalog#: C-1100 Targets: PLK4 Synonym: CFI-400945 Chemical Name/IUPAC:1R,2S)-2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one SMILES Code: O=C(NC1=C2C=C(C=C1)OC)[C@@]32[C@@H](C3)C4=CC5=C(C(/C=C/C6=CC=C(C=C6)CN7C[C@@H](O[C@@H](C7)C)C)=NN5)C=C4.O=C(O)/C=C/C(O)=O
Product Name: CFI-400945 Chemical Formula: C33H34N4O3 Molecular Weight: 534.64 CAS#: 1338806-73-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
CFI-400945 is an orally available PLK4 (polo-like kinase 4) inhibitor with potential antineoplastic activity. Upon oral administration, CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.