SKU: C-1105-5mg
CFI-400945 Chemical Formula: C33H34N4O3 Solid Powder
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  • Catalog#: C-1105
  • Targets: PLK4
  • Synonym: CFI-400945
  • Chemical Name/IUPAC:1R,2S)-2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one
  • SMILES Code: O=C(NC1=C2C=C(C=C1)OC)[C@@]32[C@@H](C3)C4=CC5=C(C(/C=C/C6=CC=C(C=C6)CN7C[C@@H](O[C@@H](C7)C)C)=NN5)C=C4.O=C(O)/C=C/C(O)=O
    Technical Data
  • Product Name: CFI-400945
  • Chemical Formula: C33H34N4O3
  • Molecular Weight: 534.64
  • CAS#: 1338806-73-7
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    CFI-400945 is an orally available PLK4 (polo-like kinase 4) inhibitor with potential antineoplastic activity. Upon oral administration, CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.