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Catalog#: C-1100 Targets: WNT Synonym: CCT251545; CCT 251545; CCT-251545 Chemical Name/IUPAC:8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one SMILES Code: O=C1NCCC12CCN(C3=C(Cl)C=NC=C3C4=CC=C(C5=CN(C)N=C5)C=C4)CC2
Product Name: CCT-251545 Chemical Formula: C23H24ClN5O Molecular Weight: 421.93 CAS#: 1661839-45-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
CCT-251545 is a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics. CCT-251545 changed gene expression regulated by WNT pathway and other on-target effects of modulating CDK8 and CDK19, including expression of genes regulated by STAT1.