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Catalog#: C-1097 Targets: p97 Synonym: CB5083; CB-5083; CB 5083 Chemical Name/IUPAC:1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
Product Name: CB-5083 Chemical Formula: C24H23N5O2 Molecular Weight: 413.4 CAS#: 1542705-92-9 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration.