SKU: C-1096
BYL-719 (Alpelisib)
$70.00
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  • Catalog#: C-1096
  • Targets: PI3K
  • Synonym: BYL719; BYL-719; BYL 719; Alpelisib
  • Chemical Name/IUPAC:(S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
    Technical Data
  • Product Name: BYL-719 (Alpelisib)
  • Chemical Formula: C19H22F3N5O2S
  • Molecular Weight: 441.47
  • CAS#: 1217486-61-7
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    BYL-719 (Alpelisib) is an orally bioavailable PI3K inhibitor with potential antineoplastic activity. BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.