SKU: C-1088
 C23H24FN9O BMS-754807 SOLID POWDER
$80.00
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  • Catalog#: C-1088
  • Targets: IGFR
  • Synonym: BMS754807; BMS-754807; BMS 754807
  • Chemical Name/IUPAC:(S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
    Technical Data
  • Product Name: BMS-754807
  • Chemical Formula: C23H24FN9O
  • Molecular Weight: 461.49
  • CAS#: 1001350-96-4
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival.