SKU: C-1083-5mg
Chemical Name: C24H25ClFN5O3 BIBW-2992 solid powder
  • Catalog#: C-1083
  • Targets: EGFR
  • Synonym: BIBW-2992; BIBW 2992; BIBW2992. Afatinib free base; Gilotrif; Tomtovok; Tovok.
  • Chemical Name/IUPAC:(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
    Technical Data
  • Product Name: BIBW-2992 (Afatinib)
  • Chemical Formula: C24H25ClFN5O3
  • Molecular Weight: 485.94
  • CAS#: 439081-18-2 (free base)
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    BIBW-2992 (Afatinib) is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. BIBW-2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types.