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Catalog#: C-1083 Targets: EGFR Synonym: BIBW-2992; BIBW 2992; BIBW2992. Afatinib free base; Gilotrif; Tomtovok; Tovok. Chemical Name/IUPAC:(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Product Name: BIBW-2992 (Afatinib) Chemical Formula: C24H25ClFN5O3 Molecular Weight: 485.94 CAS#: 439081-18-2 (free base) Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
BIBW-2992 (Afatinib) is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. BIBW-2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types.