BEZ-235 (Dactolisib)

SKU: C-1077

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Catalog#: C-1077

Targets: PI3K

Synonym: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; Dactolisib

Technical Data

Product Name: BEZ-235 (Dactolisib)

Chemical Formula: C30H23N5O

Molecular Weight: 469.54

CAS#: 915019-65-7

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
BEZ-235 (Dactolisib) is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ-235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue..

BEZ-235 (Dactolisib)

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