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Catalog#: C-1077 Targets: PI3K Synonym: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; Dactolisib
Product Name: BEZ-235 (Dactolisib) Chemical Formula: C30H23N5O Molecular Weight: 469.54 CAS#: 915019-65-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
BEZ-235 (Dactolisib) is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ-235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue..