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BEZ-235 (Dactolisib)

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SKU: C-1077-5mg
BEZ-235 (Dactolisib)
$103.99
  • Catalog#: C-1077
  • Targets: PI3K
  • Synonym: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; Dactolisib
    Technical Data
  • Product Name: BEZ-235 (Dactolisib)
  • Chemical Formula: C30H23N5O
  • Molecular Weight: 469.54
  • CAS#: 915019-65-7
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years
    Description
    BEZ-235 (Dactolisib) is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ-235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue..


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