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Catalog#: C-1076 Targets: GLUT1 Synonym: BAY-876; BAY 876; BAY876 Chemical Name/IUPAC:N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-Quinolinedicarboxamide SMILES Code: O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C=C4)C#N)N=C3C(F)(F)F)=O)=C1)N
Product Name: BAY-876 Chemical Formula: C24H16F4N6O2 Moleculer Weight: 496.42 CAS#: 1799753-84-6 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
BAY-876 is a potent and selective GLUT1 Inhibitor, with good metabolic stability in?vitro and high oral bioavailability in?vivo. GLUT1 overexpression has been reported in many types of human cancers, including those of brain,6 breast, colon, kidney, lung, ovary, and prostate, and is correlated with advanced cancer stages and poor clinical outcomes.