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Catalog#: C-1066 Targets: PI3K Synonym: AZD8186; AZD 8186; AZD-8186
Product Name: AZD-8186 Chemical Formula: C24H25F2N3O4 Moleculer Weight: 457.4 CAS#: 1627494-13-6 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
AZD-8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, AZD-8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors.