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Catalog#: C-1063 Targets: ATR Synonym: AZD-6738; AZD6738; AZD 6738
Product Name: AZD-6738 Chemical Formula: C20H24N6O2S Moleculer Weight: 412.51 CAS#: 1352226-88-0 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years
AZD-6738 is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, AZD-6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.