SKU: C-1055-5mg
 AZD-3965 Chemical Formula: C21H24F3N5O5S Moleculer Weight: 515.5 CAS#: 1448671-31-5 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO
$79.99

  • Catalog#: C-1055
  • Targets: MCT1
  • Synonym: AZD3965; AZD-3965; AZD 3965

 

Technical Data

  • Product Name: AZD-3965
  • Chemical Formula: C21H24F3N5O5S
  • Moleculer Weight: 515.5
  • CAS#: 1448671-31-5
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years

Description


AZD-3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 ?M. In vivo, AZD-3965 is well tolerated and induces a dose and time dependent accumulation of lactate in the tumours, suppresses tumour growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD-3965 offers an novel mechanism for targeting the metabolic phenotype in tumours that preferentially express MCT1.