SKU: C-1049-5mg
Product Name: AZD-1480 Chemical Formula: C14H14ClFN8 Moleculer Weight: 348.76 CAS#: 935666-88-9 Appearance: Solid powder Purity: > 99% by HPLC
$69.99

  • Catalog#: C-1049
  • Targets: JAK
  • Synonym: AZD1480; AZD-1480; AZD 1480

Technical Data

  • Product Name: AZD-1480
  • Chemical Formula: C14H14ClFN8
  • Moleculer Weight: 348.76
  • CAS#: 935666-88-9
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years


Description


AZD-1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. AZD-1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.