AZD-1208

• Catalog#: C-1048
• Targets: PIM
• Synonym: AZD1208 ; AZD-1208; AZD 1208

Technical Data

• Product Name: AZD-1208
• Chemical Formula: C21H21N3O2S
• Moleculer Weight: 379.48
• CAS#: 1204144-28-4
• Appearance: Solid powder
• Purity: > 99% by HPLC
• Solubility: Soluble in DMSO
• Storage: Room temperature for months, or -20ºC for 3 years

Description

AZD-1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD-1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.