AZD-0156
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- Catalog#: C-1045
- Targets: ATM
- Synonym: AZD0156; AZD-0156; AZD 0156
Technical Data
- Product Name: AZD-0156
- Chemical Formula: C26H31N5O3
- CAS#: 1821428-35-6
- Moleculer Weight: 461.56
- Appearance: Solid powder
- Purity: > 99% by HPLC
- Solubility: Soluble in DMSO
- Storage: Room temperature for months, or -20ºC for 3 years
Description
AVL-292 (Spebrutinib) is an orally bioavailable, selective inhibitor of BTK, with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies.