AVL-292

• Catalog#: C-1044
• Targets: BTK
• Synonym: CC292; CC-292; CC 292; AVL292; AVL-292; AVL 292

Technical Data

• Product Name: AVL-292
• Chemical Formula: C22H22FN5O3
• CAS#: 1202757-89-8
• Moleculer Weight: 423.44
• Appearance: Solid powder
• Purity: > 99% by HPLC
• Solubility: Soluble in DMSO
• Storage: Room temperature for months, or -20ºC for 3 years

Description

AVL-292 (Spebrutinib) is an orally bioavailable, selective inhibitor of BTK, with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies.