SKU: C-1034-10mg
ARQ-197 (Tivantinib) Solid powder
$89.99
  • Catalog#: C-1034
  • Targets: c-Met
  • Synonym: ARQ-197; ARQ 197; ARQ197, Tivantinib

Technical Data

  • Product Name: ARQ-197 (Tivantinib)
  • Chemical Formula: n/a
  • Moleculer Weight: 584.1
  • CAS#: 905854-02-6
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years

Description


ARQ-197 (Tivantinib) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. ARQ-197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR). This protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.