AMG-337
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- Catalog#: C-1025
- Targets: c-MET
- Synonym: AMG337; AMG-337; AMG 337
Technical Data
- Product Name: AMG-337
- Chemical Formula: n/a
- Moleculer Weight: 473.38
- CAS#: 1173699-31-4
- Appearance: Solid powder
- Purity: > 99% by HPLC
- Solubility: Soluble in DMSO
- Storage: Room temperature for months, or -20ºC for 3 years
Description
AMG-337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. AMG-337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.