AMG-337

• Catalog#: C-1025
• Targets: c-MET
• Synonym: AMG337; AMG-337; AMG 337

Technical Data

• Product Name: AMG-337
• Chemical Formula: n/a
• Moleculer Weight: 473.38
• CAS#: 1173699-31-4
• Appearance: Solid powder
• Purity: > 99% by HPLC
• Solubility: Soluble in DMSO
• Storage: Room temperature for months, or -20ºC for 3 years

Description

AMG-337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. AMG-337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.