SKU: C-1023-5mg
AMG-208 Solid Powder
  • Catalog#: C-1023
  • Targets: c-MET
  • Synonym: AMG208; AMG 208; AMG-208

Technical Data

  • Product Name: AMG-208
  • Chemical Formula: n/a
  • Moleculer Weight: 473.38
  • CAS#: 1002304-34-8
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years


AMG-208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.