SKU: C-1020-10mg
 AG-221 (Enasidenib) Solid powder
  • Catalog#: C-1020
  • Targets: IDH2
  • Synonym: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib
  • Chemical Name/IUPAC:2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
  • SMILES Code: CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1

Technical Data

  • Product Name: AG-221 (Enasidenib)
  • Chemical Formula: C19H17F6N7O
  • Moleculer Weight: 473.38
  • CAS#: 1446502-11-9
  • Appearance: Solid powder
  • Purity: > 99% by HPLC
  • Solubility: Soluble in DMSO
  • Storage: Room temperature for months, or -20ºC for 3 years


AG-221 (Enasidenib) is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of ?-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.