AEE-788

• Catalog#: C-1017
• Targets: EGFR
• Synonym: AEE788, AEE 788, AEE-788

Technical Data

• Product Name: AEE-788
• Chemical Formula: C27H32N6
• Moleculer Weight: 440.58
• CAS#: 497839-62-0
• Appearance: Solid powder
• Purity: > 99% by HPLC
• Solubility: Soluble in DMSO
• Storage: Room temperature for months, or -20ºC for 3 years

Description

AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2). Upon administration, AEE-788 results in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis.