AEE-788
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- Catalog#: C-1017
- Targets: EGFR
- Synonym: AEE788, AEE 788, AEE-788
Technical Data
- Product Name: AEE-788
- Chemical Formula: C27H32N6
- Moleculer Weight: 440.58
- CAS#: 497839-62-0
- Appearance: Solid powder
- Purity: > 99% by HPLC
- Solubility: Soluble in DMSO
- Storage: Room temperature for months, or -20ºC for 3 years
Description
AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2). Upon administration, AEE-788 results in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis.