EPZ-5676 (Pinometostat)

SKU: C-1133-5mg

Quantity (mg):

5 mg

Product Options

Quantity

$103.99

Catalog#: C-1133

Quantity: 5mg

Targets: Histone Methyltransferase

Synonym: EPZ5676; EPZ-5676; EPZ 5676; Pinometostat

Chemical Name/IUPAC:(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

Technical Data

Product Name: EPZ-5676 (Pinometostat)

Chemical Formula: C30H42N8O3

Molecular Weight: 562.7

CAS#: 1380288-87-8

Appearance: Solid powder

Purity: > 99% by HPLC

Solubility: Soluble in DMSO

Storage: Room temperature for months, or -20ºC for 3 years

Description
EPZ-5676 (Pinometostat) is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes.

EPZ-5676 (Pinometostat)

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